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Fluxomics (Dynamic Metabolomics) — concept illustration
FLUXOMICS

Fluxomics (Dynamic Metabolomics)

Metabolite levels and metabolic flux provide different information. Fluxomics measures the turnover of metabolic reactions within a living cell or organism over time. Fluxomics brings together tracing strategy, sampling design and data analysis to investigate pathway dynamics.

Discuss your project ↗
Concept illustration
01

Isotope tracing

Isotope tracing is planned for the metabolic process and experimental model. Suitability of the ¹⁸O- or ¹³C-based approaches described in our service scope is assessed for each application.

02

Targeted metabolic flux

Target pathways, sampling times and required measurements are defined from the research question. Concentration data alone are not interpreted as flux measurements.

03

Interpreting metabolic dynamics

Interpret data in the context of metabolic turnover and pathways, considering the tracing approach and computational scope.

RESEARCH FOCUS

Let’s define the focus of your study.

GlycolysisPentose phosphate pathwayKrebs cycleAmino acid metabolism
PLAN YOUR STUDY

What will you provide and receive?

Research question

Compare isotope labelling and, where appropriate, plan model-based flux estimation.

Before sending samples

Share the tracer, medium, exposure duration, sampling times and experimental groups in advance.

Deliverables

Isotopologue tables, labelling plots and a method summary as agreed; modelling may be a separate work item.

Defining the scope

Labelling distributions are not direct flux rates. Data sufficiency and model requirements are evaluated for flux estimation.

Discuss my study ↗
METABOLIC PATHWAYS

See the metabolic connections.

Explore glycolysis, the TCA cycle and connected carbon sources in one map. Isotope tracing and modelling help investigate the dynamics of these connections.

From tracing to interpretation

Isotope tracing · Pathway mapping · Metabolic flux assessment

Simplified metabolic pathway map connecting glucose, pyruvate, acetyl-CoA and the TCA cycle, with lactate, fatty acid and glutamine branches.
Illustrative pathway map — not a client result. Colours identify pathway groups, not measured flux rates or increases/decreases. Intermediate steps, cofactors and cellular compartments are simplified. TCA cycle reference: Reactome
BIOINFORMATICS

From measurements to biological interpretation.

We can discuss preprocessing, statistics and pathway interpretation as a dedicated scope.

Explore bioinformatics ↗
HOW WE WORK

A process planned together.

  1. 01

    Share your research

    Research question, samples, study groups and replicates.

  2. 02

    Define the scope

    Sample preparation, analytical approach and reporting plan.

  3. 03

    Review the results

    Agreed analyses and scope of biological interpretation.

LET’S TALK SCIENCE

Let’s start with an email.

Share your research question, analysis or manufacturing requirements. Attach drawings and relevant files to your email.

DIRECT CONTACT
Write an email ↗
Üniversiteler Mah. 1596 Cad. Teknokent Kuluçka Merkez Binası No: 6 C, Unit 11, Çankaya / Ankara, Türkiye